Clinical Data - HLA laboratories and their clinical programs should now communicate with each other and verify the IDs of typed samples. Labs and centers will need to link all IDs relating to their patients and donors. The quality of clinical data would be monitored by an oversite committee comprised of Drs. Weisdorf, Petersdorf, Horowitz, Gooley, Niederwieser and Chapman.
For those labs that have completed all high resolution typing on CML transplants, they should identify those samples for patients with acute leukemia and begin high resolution typing. IHWG and IBMTR will begin to identify all acute leukemia transplants having complete outcome data.
Microsatellites - The scientific questions were reviewed. Mary Carrington presented the microsatellites being tested. The French laboratories will send their samples to CNG. All participants are asked to make arrangements on how microsatellite testing will be completed (locally or through IHWG).
The priority samples for MS testing are the HLA-A, B, C, DRB1, DQB1 matched pairs. When labs have completed these samples, testing of HLA mismatched pairs should commence.
Cytokine Genes - The scientific questions were reviewed. Dr. Mytilineos presented CGP component and progress to date. Samples are appropriately consented from Seattle, France, Germany, NMDP, Brazil, Australia, Japan. Dr. Mytilineos stated that 20 micrograms are needed to test the entire panel of CGP. The priority samples are HLA-A, B, C, DRB1, DQB1 allele matched pairs. When labs have completed these samples, testing of mismatched pairs should commence.
NIMA - Prof. van Rood's NIMA project was summarized. Laboratories are requested to identify DNA on their haploidentical transplants that the IBMTR has verified clinical data. Laboratories should begin to type donor-recipient pairs and informative family members by high resolution methods for HLA-A, B, C, DRB1, DQB1, DPB1.
Human Subjects - Laboratories should work with their local IRBs to ensure that their consent forms include testing for microsatellite and cytokine gene polymorphisms.
Working Groups - HSCT participants are encouraged to define working groups for data analysis. Five broad groups have been formed and summarized in the attached slide. Please contact Effie Petersdorf to sign-up.
Victoria, May 2002 - Plans are underway to schedule the working group meetings during the Victoria Workshop. Please contact Effie Petersdorf for additional requests.
