Polymorphic Genes and Markers within the Human MHC

Gene Genomic Span (Kb) Coding region (nt) Accession Number Function
NOTCH4 28.5 6012 NM_004557 Transmembrane receptor; determines developmental fate of cells
HSP70-2 1.9 1926 M59830, NM_005346 Stress response protein
HSP70-1 1.9 1926 M59828, NM_005345 Stress response protein
HSP70-HOM 1.9 1926 M59829, NM_005527 Stress response protein
LTB 1.7 735 L11015 Lymphotoxin beta;
forms heterodimeric cell surface molecule (with LTA);antitumour activity
TNF alpha 1.8 702 X01394 Tumor necrosis factor alpha;antitumor activity; Neuroprotective
TNF beta
(formerly LTA)
1.0 618 D00102 Tumor necrosis factor alpha; forms heterodimeric cell surface molecule (with LTB);antitumor activity
IKBL
(NFKBIL1)
10.9 1146 X77909 I-Kappa-B-like protein (Ankyrin repeats)
Tap1
(RING4)
8.1 2247 L21208 Peptide transporter
TAP2
(RING11)
9.3 1962 AF078671 Peptide transporter
BAT2 14.9 6429 M33509 Unknown function: 4 integrin-like RGD motifs
BAT1 9.8 1287 Z37166,
NM_004640
Member of DEAD-box family of ATP-dependent RNA helicases


Courtesy http://www.path.cam.ac.uk/~mhc/map/MainMapPage.html

Typing protocols and reagents are currently being developed.