Ankylosing Spondylitis Survey

Antoine Toubert, Chair
Questionnaire for the spondyloarthropathy (ankylosing spondylitis and related arthritis) component.
AIMS OF THE STUDY: To find contributions on disease susceptibility by genes in the MHC other than HLA-B27 itself.

Please provide the following contact information:

Name

Organization

Street address

Address (cont.)

City

State/Province

Zip/Postal code

Country

Work Phone

FAX

E-mail

Are you:

an HLA typing laboratory?
an Rheumatology clinical center?

Patients

Diagnostic criteria of spondyloarthropathy:

EESG (EESG Diagnostic Criteria)
Other?
which?

Do you have access to samples of clinical forms of spondyloarthropathy?

Ankylosing spondylitis (New York criteria)
how many samples?

Reiter's syndrome/reactive arthritis (Reiter's Syndrome)
which agent?
how many samples??

Psoriatic arthropathy
how many samples?

Enteropathic spondylitis
Crohn's disease, how many samples?
Ulcerative colitis, how many samples?

Juvenile ankylosing spondylitis
how many samples?

The following items will be requested and entered for each patient:

age,

sex,

duration of the disease,

ethnical background,

family history of spondyloarthropathy,

pelvic X-ray examination,

functional assessment of disability,

and treatments (medical, surgery)

Samples

Do you have patients of ethnically homogeneous background?

Yes No
If yes, which population?
How many samples?

Is an ethnically HLA-matched control group available?
Yes No

Families (pedigree charts required):

Simplex families (one affected child with both living parents)
how many samples?

Multiplex families (more than one affected child with both living parents)
how many samples?

One parent homozygous for HLA-B27?
how many samples?

Are your samples:

already collected?
how many?

How many samples will be available at the end of 1998?
How many samples will be available at the end of 1999?

Are your already collected samples available as:

DNA
frozen lymphocytes
B lymphoblastoid cell lines

Typings

Class I typings:
serology Molecular biology

Class II subtypings;
Yes No
Method?

HLA-B27 subtyping (PCR-SSO) Yes No

If no, would you be ready to do so? Yes No

Typing Comments:

Microsatellite polymorphism typings:
Yes No
If yes, for what purpose:

Other MHC gene typing (TAP, LMP, ...)?

Do you have access to an automated DNA sequencer?
Yes No
what type?

General Comments

This survey may also be printed and faxed to Dr. A. Toubert, Laboratoire d'Immunologie et d'Histocompatibilite (Pr. D. Charron), Hopital Saint-Louis, Paris, France (33-1-42-49-44-49).

Name
Organization
Street address
Address (cont.)
City
State/Province
Zip/Postal code
Country
Work Phone
FAX
E-mail

Ankylosing Spondylitis Survey

Last revised: November 1, 1998